Endocrine Abstracts

Leptin (LEP) gene is one of the most promising candidate genes for obesity. The aim of this study was to investigate the impact of LEP polymorphisms on obesity, anthropometric and biochemical parameters in a sample of three Tunisian consanguineous families with obesity. Seven single nucleotide polymorphisms (SNPs) in 5′ region of LEP gene were genotyped in three consanguineous families including 33 individuals. The previously reported LEP</...

Background and Aims: Acute and chronic infectious diseases appear to be more prevalent among patients having diabetes mellitus. Infections associated with diabetes could be particularly serious increasing morbimortality and treatment costs. Diabetic patients’ predisposition to infections could be explained by the hyperglycemic environment impairing immune function. Other factors my contribute such as degenerative complications, for example autonomic neuropathy could decre...

Background: Patients with diabetes mellitus (DM) have been reported to have longer duration of in-hospital stay (DS). Identifying factors influencing their DS may help in the decision-making process especially in a public health setting.Aim: We aim to compare DS in patients with and without DM admitted to a medical unit in a university hospital and to determine the predictive factors of DS in patients with DM.Methods: A cross secti...

Background: Patients with Diabetes Mellitus (DM) are exposed to malnutrition, due to dietary restrictions and associated conditions. However, in daily practice, malnutrition is often under-diagnosed among these patients.Aim: To assess the risk of malnutrition in patients with DM admitted to an Endocrinology Department using the Nutritional Risk Index (NRI).Methods: We conducted a cross-sectional study to calculate the NRI in patien...

Introduction: SGLT2 (sodium-glucose cotransporter 2) inhibitors are a molecule more and more used in type 2 diabetes. However, it can cause a metabolic decompensation in some cases. Euglycemic ketoacidosis may be atypical, misplacing and delaying the diagnosis. We investigated the precipitating factors of this metabolic complication in our case study and in the literature.Presentation of the Case: We report the case of a normal BMI (19 kg/m2) ...

Introduction: Hypoglycemia is a major obstacle to glycemic control in type 1 diabetics. Approximately two episodes of symptomatic hypoglycemia occur weekly in type 1 diabetic and this risk increases with the duration of diabetes and the strict control1. The aim of this study was to identify the most frequent etiologies of hypoglycemia in hospitalized type 1 diabetic patients.Patients and Methods: This is a retrospective descriptive study that ...

Introduction: Autoimmune thyroid diseases are known to be associated with oxidative stress.Objectives: We studied the oxidative profiles in plasma and thyroid tissue of 82 patients having Graves’ disease (GD) or Hashimoto thyroiditis (HT) or hashitoxicosis (HTX) vs 65 healthy controls in order to evaluate the antioxidant enzymes’ activity and the lipid peroxidation.Results: The lipid peroxidation was objected with a signi...